Blackpool's positive display on Saturday was quickly forgotten, as promotion-casing Reading proved too strong for Barry Ferguson's well beaten side.
A hat-trick from Adam Le Fondre provided the majority of the damage, but The Seasiders were second-best throughout.
Steven Davies' stunner was the glimmer of hope taken back to Lancashire, but Pavel Pogrebnyak and Hal Robson-Kanu completed the rout for The Royals.
Trailing 2-0 after 16 minutes, Blackpool never looked like sparking a comeback on a night to forget at The Madejski Stadium.
Ferguson named an unchanged side for the trip, however they trailed after just seven minutes at a rain-socked Madejeski.
Garath McCleary's shot was deflected right into the path of Le Fondre, who confidently stroked home from close range.
McCleary already had nine assists to his name this season before today, and soon put Le Fondre through again, but the striker couldn't repeat his trick, slicing well wide.
He made up for it on 17 minutes however, as Reading threatened to run riot. Alex Pearce drifted off Isaiah Osbourne from a corner, and his header was diverted in by the deadly Le Fondre.
Blackpool's first real attempt came on the half-hour mark, when Davies fired into the side-netting from long range, but that was as good as it got during a dire first-half from a Pool perspective.
The Seasiders eventually settled into the game, and enjoyed periods of possession, but failed to create any clear cut chances.
Half Time: Reading 2 Blackpool 0
Ferguson reacted at half-time, bringing on Andy Halliday and Angel Martinez, in place of Osbourne and Nathan Eccleston.
However, five minutes into the second half it could have been all over. Jobi McAnuff's fine skill sent him through, but his low effort was fantastically saved by Matt Gilks, before Jack Robinson scrambled away the rebound from Le Fondre.
The reprieve lasted a matter of minutes however, and when Pogrebnyak was sent through he was clinical, sliding his effort out of Gilks' reach.
The goal encouraged Ferguson into making his final change before the hour-mark, with Nathan Tyson returning to his old club, coming on for Michael Chopra.
With the game looking like ebbing away from The Seasiders, a blockbuster from Davies gave them a glimmer hope with around 25 minutes.
Out of the blue, from all of 30 yards, the striker arrowed an effort into the top corner to reduce the arrears.
Pool's joy was extremely short-lived however, with Le Fondre claiming his treble, his second in successive home games, as he slipped through and lifted the ball over Gilks.
Hal Robson-Kanu then replaced the striker and forced Gilks into making a low one-handed save to keep the score down.
However, like Le Fondre in the first-half, Robson-Kanu made no mistake with his next attempt, capitalising from a ricochet, to fire past Gilks from 25 yards out.
It made it five for the hosts and ended Blackpool's misery.
Full Time: Reading 5 Blackpool 1
By Mark Ridgway