For the second time this season Blackpool left the Reebok Stadium feeling slightly hard done by, after David Wheater's solitary goal swung a tight contest Bolton's way.
In a game of few clear-cut chances, The Seasiders enjoyed large spells of possession, but were found wanting in the final third.
Wheater headed in Jay Spearing's first-half corner to win it for Wanderers, who left the more satisfied side, as they did in January's FA Cup clash.
Robert Earnshaw had arguably Blackpool's best chance, but his effort fell straight into the hands of Adam Bogdan, to deny the striker a dream debut.
Ferguson had made two changes to his side pre-match, bringing in Andy Halliday and Kevin Foley.
However it was a quiet start to proceedings, with both sides feeling each other out early on.
The first shot on goal belonged to the hosts after 12 minutes, but Lukas Jutkiewicz’s effort sailed high over the bar.
But Bolton did edge ahead soon after, Spearing’s out swinging corner was casually nodded home by Wheater, with Blackpool having nobody on the front post.
It was from another Bolton corner which Blackpool had their first chance from. Ricardo Fuller broke and slipped in Halliday, but the Scot’s powerful effort flew narrowly wide.
Pool reacted well to falling behind, next Elliot Grandin lashed an effort wide from a tight angle, after Jack Robinson’s cross eventually fell to him.
Gary MacKenzie was next to try his luck, bending a low effort wide after a comically long period of head tennis between the two sides.
At the end of the half it was Blackpool who’d had the better chances, but they were trailing due to one piece of poor defending, which they were punished for.
Half Time: Bolton 1 Blackpool 0
The Seasiders started the second half the better side, and came close when Fuller set up Grandin, whose effort was deflected over the bar.
It was the visitors who continued to have the majority of the possession, but they should have done better when Tony McMahon fired over following a short free-kick.
The pressure continued to come from Blackpool, next Robinson headed Kevin Foley’s cross wide of the mark.
Bolton’s first chance of the half came through Jermaine Beckford, but the substitute could only prod wide from Chung-Yong Lee’s through ball.
With around 20 minutes remaining Ferguson handed Earnshaw his Blackpool debut, as he replaced Grandin.
Next former-Seasider Neil Danns stung the palms of Matt Gilks, before Beckford’s header landed straight into the goalkeeper’s hands.
Andy Keogh was next to come off the bench, replacing Fuller. And the striker was soon involved, as Earnshaw spurned a great chance, shooting straight at Bogdan when well placed.
For all their possession is was incredible Pool still trailed with ten minutes remaining, next Halliday shot over as Foley was replaced by Tom Barkhuizen.
Five minutes later McMahon’s poor back pass sent Beckford through, but the striker bent his effort wide, as Bolton finished with the three points.
Full Time: Bolton 1 Blackpool 0
By Mark Ridgway