Goals from DJ Campbell and Charlie Adam condemned Reading to their first league defeat since mid-January as the Seasiders continued their play-off push.
The home side ensured back-to-back home wins with a controlled display of possession football to prevent The Royals from a fifth consecutive league win.
The Seasiders took the lead on 41 when an audacious ball from Charlie Adam found DJ Campbell to finish, before the midfielder himself rifled in from the edge of the area to seal victory with 16 minutes remaining.
Manager Ian Holloway made just the one change to the side that beat Middlesbrough on Tuesday night, Andy Butler replacing the suspended Rob Edwards.
And it was the Seasiders started like a house on fire, Brett Ormerod moving freely across the pitch. Only a great defensive clearance from Khizanishvili prevented Keith Southern from opening the scoring from the striker's teasing ball into the area.
The condition of the pitch was making the usual Blackpool playing style difficult as the ball bobbled around on the surface. The bounce of the ball was also proving to be a problem for the goalkeepers, as Adam Federici found out when scampering across goal to parry a David Vaughan effort from distance.
An injury to Gary Taylor-Fletcher forced an early substitution for the Seasiders, Hameur Bouazza coming on in his place after just 22 minutes. It initially looked as though another change would have to be made a minute later following a late challenge from Ryan Bertrand on Brett Ormerod. Luckily for the home side Brett was fit enough to stay on.
A great bit of magic from Hameur Bouazza down the right deserved a goal on the end of it but Charlie Adam blazed wide.
The visitors were forced into an early change of their own with just over 30 minutes on the clock, Brynjar Gunnarsson leaving the field to be replaced by Gylfi Sigurdsson.
It had been a pretty chanceless first-half for both sides but the Seasiders ensured that the teams wouldn't leave the field for the interval level. Charlie Adam, despite looking at full fitness following an earlier knock, split the Reading defence open with a ball off the outside of his foot and found DJ CAMPBELL who slotted the ball past Adam Federici (41). A great bit of invention from Blackpool's number 26.
BLACKPOOL 1 READING 0
The Seasiders looked to try and capitalise on their lead prior to the break for half-time but they went in the changing room just one goal ahead.
HALF-TIME SCORE - BLACKPOOL 1 READING 0
Blackpool started the second-half in the same way they started the first, this time it was Hameur Bouazza causing problems for the visitors. Charlie Adam was moving a little more freely after the restart and found himself out on the left when Pool were on the attack.
Reading replaced striker Simon Church with Gunnar Thorvaldsson on 54 as they looked to find a way back into the game. It was the Seasiders who were continuing to see more of the ball though, Hameur Bouazza forcing a fine save out of Adam Federici.
Brian McDermott made a further attacking substitution for Reading with just under an hour remaining, Gregorz Rasiak - the winning goalscorer when the two sides met at the Madejski - replacing midfielder Jem Karacan. Blackpool followed by making a change of their own, Ben Burgess coming on for Brett Ormerod.
Hameur Bouazza appeared to pick up where he left off from Tuesday night as he forced another decent save out of Federici. David Vaughan was also running the show in midfield.
The Seasiders were now finding plenty of space on the counter with less than 20 minutes remaining as Reading pushed for an equaliser. The home side wrapped the game up with a strike from the edge of the area by CHARLIE ADAM. The Scot picked up on a deflected Hameur Bouazza to fire the ball into the bottom corner (74).
BLACKPOOL 2 READING 0
The goal allowed manager Ian Holloway to bring DJ Campbell off to a standing ovation and give Stephen Dobbie 15 minutes of action. The on-loan man was coming on at a time when the Seasiders looked odds-on to get a third, Keith Southern going mightily close when hitting the post from 20-yards.
Blackpool were desperately looking for that third, and Stephen Crainey nearly became the unlikely man to get it. The left-back, who hasn't scored since his debut season in tangerine, burst into the box but just couldn't bundle the ball in.
In the end it was a comfortable victory for the Seasiders, with Reading barely mustering a real attempt on goal.
FULL-TIME SCORE - BLACKPOOL 2 READING 0
Attendance: 7,147 (519 visitors)