Scunthorpe got proceedings underway on a chilly but dry Good Friday afternoon and after just minutes the hosts had forced the first corner of the afternoon but Matt Gilks did well to come through and confidently collect the McCann set play.
Gilks was on hand two minutes later to race off his line to hoof clear after a great ball from McCann had opened the Pool back four.
Keith Southern forced Pool's first corner less than a minute later, but Billy Clarke's cross was a touch too high for the target Alex Baptiste and Scunthorpe were able to clear.
A great cross from Charlie Adam was met by the head of Gary Taylor-Fletcher at the far post and unfortunately for Pool the powerful header on seven minutes drifted the wrong side of the post with Murphy scrambling.
In a frantic opening, Scunthorpe forced another corner but after both sides had been warned about pushing and shoving the referee penalised the hosts and Pool cleared.
Pool were denied an opener on 13 minutes by a fantastic save by Joe Murphy, Gary Taylor-Fletcher sent Stephen Dobbie racing clear, the on-loan Swansea man found himself one on one with the Irish keeper but Murphy produced a fine save to deny Dobbie's curling finish.
The twenty minute mark saw Ben Burgess glance a Billy Clarke cross just wide, had the ball drifted on the right side of the post Pool would have been in front as Murphy was rooted to the spot.
In his pre-match press conference, Pool boss Ian Holloway said with a bit of luck anything was possible, well on 22 minutes Lady Luck smiled on The Seasiders, Seamus Coleman's long ball towards Ben Burgess from the right was a little high for the big striker but fortunately for Pool ANDREW WRIGHT who was under pressure from Burgess fired beyond his own keeper to give Pool the lead.
Charlie Adam tired his usual long range effort from the half way line on 29 minutes but the effort was a tame one and caused Joe Murphy no problems.
A Charlie Adam free kick was turned behind for a corner on 31 minutes, but Joe Murphy was on hand to collect Billy Clarke's resulting set play with ease.
Stephen Dobbie's persistence on 35 minutes almost doubled the Seasiders lead, the Pool front man spotted Murphy off his line and tried to lobthe Iron keeper after he had charged down Wright's clearance.
Andrew Wright became the first player in the book on 37 minutes after he handled Stephen Dobbie's knock down, the resulting free kick saw Charlie Adam drill a low one across goal, somehow the ball eluded the on rushing Alex Baptiste, Ben Burgess and Ian Evatt.
Three minutes before the break the home side forced a corner but the Pool defence stood firm.
Stephen Dobbie's curling cross just before the break almost doubled Pool's lead, the ball ricocheted off Raynes, but fortunately for the former Stockport man the ball flew in the arms of Murphy.
At the other end Matt Gilks did well to claim a right wing corner at the second attempt, moments later Gilks was forced to tip over Thompson's finish after Scunthorpe opened up the Pool defence.
Half Time Scunthorpe 0 Blackpool 1
First Half Stats
Attempts On Target
Attempts Off Target
The second period saw Pool start brightly but in their first foray forward Scunthorpe were awarded a penalty on 48 minutes, Joe Martin conceded possession in the centre circle and the hosts broke forward at pace, Ian Evatt caught GRANT McCANN inside the box and referee Andy Woolmer had no hesitation in pointing to the spot McCANN stepped up and made no mistake sending Matt Gilks the wrong to put the scores level.
Three minutes later Ian Evatt became the first Pool player to be booked following another foul on Grant McCann.
Charlie Adam forced Murphy into a fine save on 51 minutes with a sweetly struck left foot strike from 25 yards.
In a pulsating opening to the second half Scunthorpe forced a corner this time Alex Baptiste was able to clear McCann's teasing cross.
Ian Evatt missed a golden opportunity to make amends when he found himself unmarked by a great free kick from Charlie Adam, but the big centre back could only glance his header wide.
Stephen Dobbie fired wide on 61 minutes after he was found wide on the right by a long raking pass from Charlie Adam.
Pool made a double change on 64 minutes, Stephen Dobbie made way for Hameur Bouazza whilst David Vaughan replaced Billy Clarke.
Matt Sparrow forced Matt Gillks to tip over for a corner with 20 minutes remaining as Scunthorpe threatened to steal the points.
Joe Murphy saved Scunthorpe on 75 minutes, Hameur Bouazza sent Charlie Adam clear, the Scottish international unselfishly squared to the unmarked Gary Taylor-Fletcher who looked certain to score but Murphy produced a fantastic save to deny the Seasiders.
With the one or two beginning to think that it wasn't to be The Tangerines afternoon, SEAMUS COLEMAN picked up the ball from a throw on the right and weaved his way past several challenges before smashing past Joe Murphy to send the 1,323 Pool supporters into raptures.
DJ CAMPBELL replaced Gary Taylor-Fletcher shortly after the goal and few would have thought his introduction would have been so inspirational, the Leicester front man had been on the field a matter of five minutes when he made it 3-1, Hameur Bouazza got in front of his man to head a great cross home, three minutes later Charlie Adam burst forward and was set to make it 4-1 his effort was blocked by Wright but Campbell was on hand to fire home.
GARY HOOPER pulled one back a minute later when he got on the end of a Thompson cross.
David Vaughan saw a shot blocked behind for a corner 90 seconds from time, but Pool failed to test Murphy.
Ben Burgess had the ball in the net in stoppage time, but his effort was chalked off for off-side.
The win was greeted by a standing ovation from the Pool supporters, Monday's clash with Doncaster is another big one, make sure you don't miss it!
Attempts On Target
Attempts Off Target
Pool: Gilks, Coleman , Baptiste, Evatt, Martin, Southern, Adam, Taylor-Fletcher (Campbell 78), Clarke (Vaughan 64), Burgess, Dobbie (Bouazza 64) Subs Not Used: Rachubka, Edwards, Euell, Bannan
Scunthorpe: Murphy, Wright, Williams, Togwell (Wright 87), Milne, Sparrow (Hooper 79), McCann, Hayes, Thompson, Woolford, (McDermott 52) Raynes Subs Not Used: Lillis, O'Connor, Canavan, McNulty
Referee: Andy Woolmer (Northamptonshire)
Attendance: 7,508 (1,323 Away)