Blackpool secured their first win at St James' Park in thirty years with a classic display of counter-attacking football.
Charlie Adam made it 1-0 with a penalty just before the break after Luke Varney was felled in the box.
Newcastle dominated much of the second half but were thwarted by the excellent Matthew Gilks who denied the Magpies on numerous occasions.
But it was the Seasiders who doubled their lead and secured a 2-0 victory when DJ Campbell capped his return to the club with a wonderful bending effort late on.
Ian Holloway made three changes from the 2-2 draw with Fulham as Alex Baptiste, Craig Cathcart and Gary Taylor-Fletcher made way for Dekel Keinan, Neil Eardley and the returning DJ Campbell.
Blackpool made a positive start at St James' Park as Campbell went close with an early scissor-kick.
The striker could and should have opened the scoring on the 11 minute mark, running on to Charlie Adam's delightful through ball, only to see his effort parried by Harper.
Brett Ormerod followed up the rebound but his shot was deflected behind for a corner kick.
Newcastle, buoyed by four points from their last six including the 6-0 thrashing of Aston Villa two weeks ago, came within inches of taking the lead.
Winger Wayne Routledge twisted and turned down the right hand side of the box before hanging a wonderful cross on to the head of Mike Williamson who headed against the post.
Both sides looked dangerous in attack and when Campbell slotted home from Grandin's deft pass on 34 minutes the Seasiders looked to have broken the deadlock.
But referee Lee Mason raised his flag to the relief of the home crowd.
The Tangerines weren't to be denied for much longer as Luke Varney gave the Newcastle defence twisted blood before Alan Smith brought the new signing down with a clumsy tackle.
Adam stepped up and silenced the home support with a coolly taken penalty that sent Harper the wrong way to make it 0-1 to the visitors at the break.
The Magpies emerged for the second half revitalised with the words of manager Chris Hughton no doubt ringing in their ears.
And five minutes in Kevin Nolan played in Carroll eight yards from goal but Gilks was out quickly to smother and keep the Seasiders in front.
The home side continued to press and Joey Barton forced the Scottish international into another magnificent save on 61 minutes.
The midfielder stumbled past three Blackpool defenders and slid the ball towards the bottom right hand corner, but Gilks was equal to it.
In an attempt to alleviate the growing pressure, Ian Holloway brought on Marlon Harewood to face his former club in place of Ormerod.
The Newcastle faithful began to show their frustration as they struggled to break down a resilient Blackpool rearguard.
And Fabricio Coloccini reflected the growing discontent with a scything challenge on Campbell that drew a yellow card from Mason.
Routledge continued to cause trouble in the final third, forcing a goal line clearance from Neil Eardley with the home support already celebrating.
With seven minutes remaining Blackpool shuffled their pack as Holloway replaced Varney and Grandin with new signing David Carney and the returning Keith Southern.
Gilks continued to be the visitor's saviour, coming to the rescue again on 88 minutes.
The in-form Carroll found himself free eight yards from goal and unleashed a fearsome effort that looked destined for the back of the net but the keeper thrust out a telescopic left foot that diverted the ball over the bar.
And with Newcastle running out of ideas it was Blackpool who stunned St James' Park with a killer second goal.
Adam burst forward unopposed and played the ball to Campbell on the edge of the box who evaded the attentions of the Newcastle defence and bent a wonderful effort into the bottom left corner.
The final whistle cued ecstatic celebrations from the travelling away support as Blackpool pulled off a smash-and-grab victory to make it seven points from the opening four Barclays Premier League games.