Three first half Leeds United goals killed any momentum Blackpool had building, as Lee Clark's side left Elland Road empty handed.
The Yorkshiremen hit Pool for three before the break, and although Nile Ranger replied for The Seasiders, it counted for little in terms of the contest.
Liam Cooper, Souleymane Doukara and Mirco Antenucci all punished sloppy Blackpool defending to leave them bottom of The Championship.
Although the visitors pulled one back through Ranger's header, the damage had been done, and they left West Yorkshire defeated.
The hosts, who were without a win in eight matches, saw Antenucci denied by Joe Lewis just two minutes in, however it was simply the warning signs of what was to come.
Moments later their early pressure told, as Cooper thundered an effort past Lewis from the edge of the area.
Blackpool's hosts were looking by far the hungrier side, and it could have been two when Antenucci's effort skimmed the correct side of the net from a Pool perspective.
However they wouldn't be so lucky on 31 minutes, as a brisk counter attack led by Antenucci was finished off when Doukara slid home their second.
And a truly dismal first half for Blackpool was compounded when Charles Dunne's poor clearance fell straight to Antenucci, whose return effort deflected off the defender on its way into the Pool net.
As the half entered stoppage time Blackpool managed to carve out two-half chances. First Ishmael Miller saw his goal-bound effort blocked, before Peter Clarke headed over from the following corner.
It meant The Seasiders went in three goals behind at the break.
Half Time: Leeds 3 Blackpool 0
At the break Lee Clark opted to make his second change, replacing Andrea Orlandi with Ranger.
The substitution did little to improve things on the pitch for Pool however, even when Jacob Murphy's corner was met by Ranger, the striker couldn't steer it goal-wards.
David Perkins was next to try his luck, firing narrowly wide on 62 minutes, before Doukara's weak effort was held by Lewis at the other end.
The introduction of Jacob Mellis was next for Blackpool, and the midfielder set up Murphy soon after, whose shot was put behind for a corner.
And from the resulting set piece The Seasiders got themselves on the score sheet, as Ranger met Murphy's corner with a fine glancing header.
The goal kicked Pool into life momentarily, but Miller's low drive failed to reduce the deficit further and it meant Blackpool will remain on seven points for the upcoming international break.
Full Time: Leeds 3 Blackpool 1
By Mark Ridgway