A goal in each half saw Blackpool win in the capital and move into the League Two play-off positions.
Jamille Matt’s third goal in as many matches put them in front at Leyton Orient, as the striker powered through and fired high into the net.
After the break Tom Aldred’s first goal of the season, a typical bullet header, put the seal on Pool’s second away win of the season.
It wasn’t to be the comfortable ending they’d have hoped for as Paul McCallum’s header reduced the deficit but Pool held on.
Leyton Orient started on the front foot in the capital and Nigel Atangana’s ambitious effort needed saving by Sam Slocombe. However, seconds later Blackpool had a big chance to take the lead as Jack Payne brilliantly found Brad Potts but the midfielder was denied by Alex Cisak.
That chance livened up the contest and Slocombe saved from Gavin Massey, although the linesman’s flag had him covered anyway.
The Seasiders were asking more questions as the half wore on and Colin Daniel could have done better when volleying over on his preferred left foot.
So when the opening goal arrived Orient couldn’t have said it wasn’t coming. Matt bullied Yvan Erichot off the ball, poised himself and fired into the roof of the net – thoroughly deserved for Blackpool’s best player so far.
However, Orient almost instantly reacted and Massey’s brilliant effort moved at the right time from a Pool perspective and cannoned off the post and away to safety.
Not affected by that chance, Andy Taylor curled a free-kick which needed putting behind by Cisak before Kyle Vassell sliced over from the following corner.
Michael Collins did have the ball in the Pool net, but it was ruled out for offside after the midfielder rounded Slocombe. Late on in the half The Seasiders started to sit back and Collins almost equalised as his effort was deflected wide.
There was to be one final chance of the half however after Potts found Colin Daniel, the midfielder broke free but was eventually thwarted by Cisak as The Seasiders went in for the break 1-0 up.
Half-Time: Leyton Orient 0 Blackpool 1
It was more of the same after the break and Vassell finished a brisk counter attack by forcing Cisak to parry behind for a corner. And they gave themselves breathing space on 58 minutes as Aldred powered home Jack Payne’s corner for 2-0.
There was more to come from The Seasiders as well and Kelvin Mellor fizzed an effort narrowly over the bar. With Pool ahead their top scorer Vassell wanted in on the action and fired a shot just wide on 72 minutes.
Potts was next to threaten a third and his clipped effort was kept out by Tom Parkes rushing back. Soon after Jim McAlister took the place of Daniel as Pool looked to see out the win.
Sandro Semedo had two efforts fly off target for the hosts, whose poor home form was on its way to worsening. Former Orient man Armand Gnanduillet then replaced Matt with six minutes to go.
Orient breathed new life into the contest a minute from time as substitute McCallum’s brilliant header evaded the outstretched arm of Slocombe for 2-1. And they could have equalised, had it not been for a tremendous block from Clark Robertson to deny Robbie Weir.
With seconds remaining Danny Philliskirk replaced Vassell in a bid to give Pool fresh legs and they did the trick as Slocombe claimed a long ball and Pool had won.
Full-Time: Leyton Orient 1 Blackpool 2