Goals from Thomas Ince and Ludovic Sylvestre in either half handed The Seasiders a well deserved win at Hillsborough.
Chris Basham was making his first start of the season and added some much needed steel to the middle of the park in the city it was famous for.
It was a lively opening from both sides and with just four minutes on the clock Michail Antonio latched onto a through ball, rounded Matt Gilks but ended up taking the ball too wide and then failed to find a team mate in the middle and Blackpool could clear.
The Seasiders almost took the lead themselves through Matt Phillips, who collected the ball after some great work from Elliot Grandin, but his shot clipped the crossbar from 25 yards out.
Blackpool continued to look dangerous in the early stages with the front three of Thomas Ince, Gary Taylor-Fletcher and Matt Phillips combining well on several occasions.
The Seasiders then took a deserved lead on eighteen minutes with a superb team goal, which Ince finished off.
Matt Phillips cut inside off the left flank, played a perfectly weighted reverse ball to the onrushing Grandin whose first time cross was tapped in by Ince.
GOAL: Sheffield Wednesday 0-1 BLACKPOOL
Steve Thompson's side continued to look comfortable in possession and passed the ball around well in the opening half-hour with Gilks rarely called into action.
A burst through the midfield from Basham soon after the 30-minute mark almost resulted in a second goal for The Seasiders but Taylor-Fletcher was unable to get on the end of Matt Phillips' teasing cross.
Despite Blackpool having the majority of the play Sheffield Wednesday had a very useful outlet in the form of the pacy Antonio.
He began to cause problems once again towards the end of the half as he continued to look to get in behind the Pool defence and stretch The Seasiders, but without ever troubling Gilks.
The last action of the half was a Ross Barkley effort from the edge of the box that he dragged wide, meaning The Seasiders had a deserved but slender lead at the break.
HALF-TIME: SHEFFIELD WEDNESDAY 0-1 BLACKPOOL
Into the second half and it was Antonio causing Blackpool problems again as he got on the end of a long ball over the top before lashing the ball high and wide as he was bearing down on goal.
The home side came out with more purpose in the second period and almost got back on level terms but McCabe's curling shot from the edge of the penalty area went narrowly over Gilks' crossbar with the keeper rooted to the spot.
The next chance fell to Blackpool and but for the crossbar it would have been 2-0 as Neal Eardley's right-wing cross found Taylor-Fletcher at the far post but his header rattled the bar.
As the game entered the final third it became slightly more scrappy with both teams struggling to keep hold of the ball and tackles flying in from all directions.
Grandin then had a half-chance as he met Stephen Crainey's near post cross only to mistime his jump and send his looping header over.
The Seasiders then comfortably soaked up some pressure from the home side before they hit The Owls on the counter-attack and doubled their advantage.
Substitute Nathan Delfouneso carried the ball into the area after beating a man and shot low across Chris Kirkland, who could only parry and Sylvestre was on hand to apply the finish from close range.
GOAL: Sheffield Wednesday 0-2 BLACKPOOL
The goal knocked the stuffing out of the home side with the Basham mopping up everything in midfield and winning almost every second ball.
The Seasiders were resolute throughout and saw out the game comfortably to take all three points.
FULL-TIME: SHEFFIELD WEDNESDAY 0-2 BLACKPOOL